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Human protein reference database—2006 update

  1. Akhilesh Pandey2,3,4,*

+ Author Affiliations

  1. 1Institute of Bioinformatics, International Tech Park Bangalore 560 066, India
  2. 2McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University Baltimore, MD 21205, USA
  3. 3Department of Biological Chemistry, Johns Hopkins University Baltimore, MD 21205, USA
  4. 4Department of Oncology, Johns Hopkins University Baltimore, MD 21205, USA
  1. *To whom correspondence should be addressed at McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, 733 N. Broadway, BRB Room 569, Baltimore, MD 21205, USA. Tel: +1 410 502 6662; Fax: +1 410 502 7544; Email: pandey@jhmi.edu
  • Received September 15, 2005.
  • Revision received October 27, 2005.
  • Accepted October 27, 2005.

Abstract

Human Protein Reference Database (HPRD) (http://www.hprd.org) was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein–protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein–protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (http://www.genprot.org), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data.

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    1. 34 (suppl 1): D411-D414. doi: 10.1093/nar/gkj141

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