Human protein reference database—2006 update
- Gopa R. Mishra1,
- M. Suresh1,
- K. Kumaran1,
- N. Kannabiran1,
- Shubha Suresh1,
- P. Bala1,
- K. Shivakumar1,
- N. Anuradha1,
- Raghunath Reddy1,
- T. Madhan Raghavan1,
- Shalini Menon1,
- G. Hanumanthu1,
- Malvika Gupta1,
- Sapna Upendran1,
- Shweta Gupta1,
- M. Mahesh1,
- Bincy Jacob1,
- Pinky Mathew1,
- Pritam Chatterjee1,
- K. S. Arun1,
- Salil Sharma1,
- K. N. Chandrika1,
- Nandan Deshpande1,
- Kshitish Palvankar1,
- R. Raghavnath1,
- R. Krishnakanth1,
- Hiren Karathia1,
- B. Rekha1,
- Rashmi Nayak1,
- G. Vishnupriya1,
- H. G. Mohan Kumar1,
- M. Nagini1,
- G. S. Sameer Kumar1,
- Rojan Jose1,
- P. Deepthi1,
- S. Sujatha Mohan1,
- T. K. B. Gandhi1,
- H. C. Harsha1,
- Krishna S. Deshpande1,
- Malabika Sarker1,
- T. S. Keshava Prasad1 and
- Akhilesh Pandey2,3,4,*
+ Author Affiliations
- *To whom correspondence should be addressed at McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, 733 N. Broadway, BRB Room 569, Baltimore, MD 21205, USA. Tel: +1 410 502 6662; Fax: +1 410 502 7544; Email: pandey@jhmi.edu
- Received September 15, 2005.
- Revision received October 27, 2005.
- Accepted October 27, 2005.
Abstract
Human Protein Reference Database (HPRD) (http://www.hprd.org) was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein–protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein–protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (http://www.genprot.org), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data.
- © The Author 2006. Published by Oxford University Press. All rights reserved
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