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Atmospheric methane levels increased over geological formations in Northern Siberia following a heat wave in 2020, suggesting that permafrost thaw releases methane from reservoirs.
Image credit: Wikimedia Commons.
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Contributed by Richard M. Karp, July 25, 2003
Abstract
We implement a strategy for aligning two protein–protein interaction networks that combines interaction topology and protein sequence similarity to identify conserved interaction pathways and complexes. Using this approach we show that the protein–protein interaction networks of two distantly related species, Saccharomyces cerevisiae and Helicobacter pylori, harbor a large complement of evolutionarily conserved pathways, and that a large number of pathways appears to have duplicated and specialized within yeast. Analysis of these findings reveals many well characterized interaction pathways as well as many unanticipated pathways, the significance of which is reinforced by their presence in the networks of both species.
Footnotes
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↵‡ To whom correspondence should be sent at the present address: University of California at San Diego, Department of Bioengineering, 9500 Gilman Drive, La Jolla, CA 92093. E-mail: trey@bioeng.ucsd.edu.
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Abbreviation: MAPK, mitogen-activated protein kinase.
- Copyright © 2003, The National Academy of Sciences
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