Skip to main content
Home
  • Log in
  • My Cart

Advanced Search

  • Home
  • Articles
  • Front Matter
  • News
  • Podcasts
  • Authors
  • Submit
Research Article

Evolution of resilience in protein interactomes across the tree of life

Marinka Zitnik, Rok Sosič, Marcus W. Feldman, and Jure Leskovec

    See allHide authors and affiliations

    PNAS March 5, 2019 116 (10) 4426-4433; first published February 14, 2019; https://doi.org/10.1073/pnas.1818013116
    1. Contributed by Marcus W. Feldman, December 18, 2018 (sent for review October 19, 2018; reviewed by Edoardo Airoldi and Aviv Bergman)

    • Article
    • Figures & SI
    • Info & Metrics
    • PDF

    Online Impact

     

    Article Information

    vol. 116 no. 10 4426-4433
    DOI: 
    https://doi.org/10.1073/pnas.1818013116
    PubMed: 
    30765515

    Published By: 
    National Academy of Sciences
    Print ISSN: 
    0027-8424
    Online ISSN: 
    1091-6490
    History: 
    • Published in issue March 5, 2019.
    • Published first February 14, 2019.

    Article Versions

    • Previous version (February 14, 2019 - 11:47).
    • You are viewing the most recent version of this article.
    Copyright & Usage: 
    Copyright © 2019 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

    Author Information

    1. Marinka Zitnika,
    2. Rok Sosiča,
    3. Marcus W. Feldmanb,1, and
    4. Jure Leskoveca,c,1
    1. aDepartment of Computer Science, Stanford University, Stanford, CA 94305;
    2. bDepartment of Biology, Stanford University, Stanford, CA 94305;
    3. cChan Zuckerberg Biohub, San Francisco, CA 94158
    1. Contributed by Marcus W. Feldman, December 18, 2018 (sent for review October 19, 2018; reviewed by Edoardo Airoldi and Aviv Bergman)

    Footnotes

    • ↵1To whom correspondence may be addressed. Email: mfeldman@stanford.edu or jure@cs.stanford.edu.
    • Author contributions: M.Z., M.W.F., and J.L. designed research; M.Z., R.S., and J.L. performed research; M.Z., R.S., M.W.F., and J.L. analyzed data; and M.Z., R.S., M.W.F., and J.L. wrote the paper.

    • Reviewers: E.A., Harvard University; and A.B., Albert Einstein College Of Medicine.

    • The authors declare no conflict of interest.

    • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1818013116/-/DCSupplemental.

    Cited By...

    • 15 Citations
    • 18 Citations
    • Google Scholar

    Article usage

    Article usage: February 2019 to January 2022

    AbstractFullPdf
    AbstractFullPdf
    Feb 2019656832283
    Mar 20191228839330
    Apr 201927388144
    May 20195427382
    Jun 20192320070
    Jul 20195136296
    Aug 20192615762
    Sep 201912921056
    Oct 20193115767
    Nov 20193412966
    Dec 20193213547
    Total 2019229136821303
    Jan 20201211437
    Feb 20201315528
    Mar 20201417441
    Apr 20203515669
    May 20202811051
    Jun 20202314143
    Jul 20201221458
    Aug 20203016691
    Sep 20201418762
    Oct 20202616657
    Nov 20201613546
    Dec 20202411531
    Total 20202471833614
    Jan 20212312241
    Feb 20211614152
    Mar 20211819047
    Apr 20212011240
    May 20211311538
    Jun 2021178926
    Jul 2021109539
    Aug 2021169970
    Sep 2021912969
    Oct 20211914472
    Nov 202126152134
    Dec 2021617645
    Total 20211931564673
    Jan 2022071
    Total 2022071
    Total273170862591
    PreviousNext
    Back to top
    Article Alerts
    Email Article
    Citation Tools
    Request Permissions
    Share
    • Tweet Widget
    • Mendeley logo Mendeley

    Article Classifications

    • Biological Sciences
    • Evolution
    Proceedings of the National Academy of Sciences: 116 (10)
    Table of Contents

    Submit

    Sign up for Article Alerts

    Jump to section

    • Article
      • Abstract
      • Results
      • Discussion
      • Materials and Methods
      • Acknowledgments
      • Footnotes
      • References
    • Figures & SI
    • Info & Metrics
    • PDF

    You May Also be Interested in

    Honeycomb photographed in the field. Image credit: Michael L. Smith.
    Comb construction in honeybees
    Honeybees construct perfectly hexagonal combs and surmount architectural challenges by altering their building behavior.
    Image credit: Michael L. Smith.
    Deodorant spray. Image credit: iStock/michalPuchala.
    Volatile chemical products and ozone formation
    Volatile chemical products found in personal care and cleaning products generate ozone and are widespread in cities in the United States and Europe.
    Image credit: iStock/michalPuchala.
    Speleothem of Cueva Ardales, with archaeological trench in the foreground. Image credit: Pedro Cantalejo-Duarte.
    Pigment composition in Neanderthal paintings
    Neanderthals developed a form of cave art before the arrival of anatomically modern humans in Europe.
    Image credit: Pedro Cantalejo-Duarte.
    Three test tubes with lethal doses of heroin, carfentanil, and fentanyl.
    Inner Workings: Vaccines aim to fight drugs of abuse
    Researchers hope vaccines can serve as a key tool for addressing the opioid epidemic. The first clinical trials are underway, though big challenges remain.
    Image credit: United States Drug Enforcement Administration.
    Factories belch pollution into a hazy sky as the sun peaks out from behind the clouds.
    Journal Club: How to incorporate changing human behaviors into planetary models
    Eyeing the effects of the Anthropocene, researchers offer a novel framework to identify and combine models from across the physical and social sciences.
    Image credit: Shutterstock/Victor Lauer.

    Similar Articles

    • The molecular evolution of feathers with direct evidence from fossils
    • Epistasis produces an excess of invariant sites in neutral molecular evolution
    • Microbial population dynamics and evolutionary outcomes under extreme energy limitation
    • How market ecology explains market malfunction
    • Thermal adaptation of mRNA secondary structure: stability versus lability
    See more
    Site Logo
    Powered by HighWire
    • Submit Manuscript
    • Twitter
    • Youtube
    • Facebook
    • RSS Feeds
    • Email Alerts

    Articles

    • Current Issue
    • Special Feature Articles – Most Recent
    • List of Issues

    PNAS Portals

    • Anthropology
    • Chemistry
    • Classics
    • Front Matter
    • Physics
    • Sustainability Science
    • Teaching Resources

    Information

    • Authors
    • Editorial Board
    • Reviewers
    • Subscribers
    • Librarians
    • Press
    • Cozzarelli Prize
    • Site Map
    • PNAS Updates
    • FAQs
    • Accessibility Statement
    • Rights & Permissions
    • About
    • Contact

    Feedback    Privacy/Legal

    Copyright © 2022 National Academy of Sciences. Online ISSN 1091-6490. PNAS is a partner of CHORUS, COPE, CrossRef, ORCID, and Research4Life.